CAROLINE (Dushku) - code name "Echo" - is an "Active," a member of a highly illegal and underground group of individuals who have had their personalities wiped clean so they can be imprinted with any number of new personas. Hired by the wealthy, powerful and connected, the Actives don't just perform their hired roles, they wholly become - with mind, personality and physiology - whomever the client wants or needs them to be. Whether imprinted to be a lover, an assassin, a corporate negotiator or a best friend, the Actives know no other life than the specific engagements they are in at that time.
Confined between missions to a secret facility known as the "Dollhouse," Echo and the other Actives, including SIERRA (Dichen Lachman) and VICTOR (Enver Gjokaj), are assigned engagements by ADELLE DEWITT (Olivia Williams), one of the Dollhouse's leaders. After each scenario, Echo, always under the watchful eye of her handler, turned head-of security, BOYD LANGTON (Harry Lennix), returns to the mysterious Dollhouse where her thoughts, feelings, experiences and knowledge are erased by TOPHER BRINK (Fran Kranz), the Dollhouse's genius programmer. Echo enters the next scenario with no memory of before - or does she? - as she seemingly begins to remember her original memories and slowly pieces together her mysterious past.
Former FBI Agent PAUL BALLARD (Tahmoh Penikett) determined to solve the mystery of the DOLLHOUSE and find the missing Caroline, accomplished his goal in the first season finale and was convinced (or was it coerced?) to become Echo's new handler. DOLLHOUSE revolves around Echo's blossoming self-awareness and her desire to discover her true identity. But with each new engagement, comes a new memory and increased danger inside and outside the Dollhouse.